Category: Lamc1 protein

Lamc1 protein

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.

Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma formerly A, B1, and B2, respectivelyhave a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains.

Laminin subunit gamma-1

Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo.

This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II.

LAMC1 protein

The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly.

It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs 5.

Catalog No. Contact our Customer Service for availability and price in your country. Delivery in 19 to 20 Business Days. Delivery in 15 to 19 Business Days. Delivery in 12 to 19 Business Days. Type Protein Protein. Human Mouse Rat. Escherichia coli E. Liquid Lyophilized. Protein Summary. You are here: Homepage Homepage Laminin gamma 1 Proteins.LAMC1 involved in several pathways and played different roles in them. Also, other proteins which involved in the same pathway with LAMC1 were listed below.

Creative BioMart supplied nearly all the proteins listed, you can search them on our site. LAMC1 has several biochemical functions, for example, extracellular matrix structural constituent, glycosphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMC1 itself.

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You can find most of the proteins on our site. LAMC1 has direct interactions with proteins and molecules.

lamc1 protein

Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMC1. Paez, MC; Matsuura, E; et al. Laminin-1 LM in preeclampsia and systemic lupus erythematosus. Vafia, K; Groth, S; et al. Pathogenicity of Autoantibodies in Anti-p Pemphigoid.

Follow Us. All Rights Reserved. Terms and Conditions Privacy Policy. Keywords search Gene search Google search. Species : Human Mouse Rat Zebrafish. Source : E. Protein Expression and Purification.

Protein Interaction Analysis. Ion Channel Screening. GPCR Screening. Recombinant Protein. Native Protein. Enter your email here to subscribe. Easy access to products and services you need from our library via powerful searching tools. Laminins are major proteins in the basal lamina one of the layers of the basement membranea protein network foundation for most cells and organs.Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes.

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They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma formerly A, B1, and B2, respectivelyhave a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains.

Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.

The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II.

The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs 5.

Gene Ontology GO annotations related to this gene include extracellular matrix structural constituent and glycosphingolipid binding. An important paralog of this gene is LAMC3.

Genes Participants. Jump to section. Antibodies Assays Proteins Inhib. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma formerly A, B1, See more Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein attributes for LAMC1 Gene Size: amino acids Molecular mass: Da Quaternary structure: Laminin is a complex glycoprotein, consisting of three different polypeptide chains alpha, beta, gammawhich are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Gamma-1 is a subunit of laminin-1 laminin or EHS lamininlaminin-2 laminin or merosinlaminin-3 laminin or S-lamininlaminin-4 laminin or S-merosinlaminin-6 laminin or K-lamininlaminin-7 laminin or KS-lamininlaminin-8 lamininlaminin-9 lamininlaminin laminin and laminin laminin Abcam antibodies for LAMC1.

Biorbyt antibodies for LAMC1. Browse Sino Biological Antibodies. Browse ProSpec Recombinant Proteins. Abcam proteins for LAMC1. Browse Sino Biological Assays. Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.

Domains VI and IV are globular. Genes that share domains with LAMC1: view. Genes that share ontologies with LAMC1: view. Genes that share phenotypes with LAMC1: view. Browse GeneCopoeia Cell Lines. Compartment Confidence extracellular 5 endoplasmic reticulum 5 plasma membrane 2 cytoskeleton 2 nucleus 2 mitochondrion 1 peroxisome 1 endosome 1 cytosol 1 lysosome 1 golgi apparatus 1.

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Endoplasmic reticulum 2 Plasma membrane 2 See all subcellular structures.Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max.

Automatic assertion inferred from database entries i. Automatic assertion according to sequence analysis i. Automatic assertion according to rules i. You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser. Basket 0. Your basket is currently empty.

Submitted name: LAMC1 protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence s displayed.

Select a section on the left to see content. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. ModBase i Search Gene3D i 2. The information is filed in different subsections. Length: Mass Da : 27, It is useful for tracking sequence updates.

Laminin, gamma 1

The algorithm is described in the ISO standard. Sinocyclocheilus anshuiensis. Full view. These are stable identifiers and should be used to cite UniProtKB entries.Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Manual assertion according to rules i. Manual assertion based on experiment in i.

lamc1 protein

Comprehensive resource for the study of protein post-translational modifications PTMs in human, mouse and rat. Laminin is a complex glycoprotein, consisting of three different polypeptide chains alpha, beta, gammawhich are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Gamma-1 is a subunit of laminin-1 laminin or EHS lamininlaminin-2 laminin or merosinlaminin-3 laminin or S-lamininlaminin-4 laminin or S-merosinlaminin-6 laminin or K-lamininlaminin-7 laminin or KS-lamininlaminin-8 lamininlaminin-9 lamininlaminin laminin and laminin laminin Manual assertion inferred from combination of experimental and computational evidence i.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped. Show all Align All. You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser. Basket 0.

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Your basket is currently empty. Laminin subunit gamma Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence s displayed. Select a section on the left to see content. Cell Res. Cell Biol. Alternative name s :. S-laminin subunit gamma Short name:. Endoplasmic reticulum endoplasmic reticulum lumen Source: Reactome Extracellular region or secreted basement membrane Source: UniProtKB Inferred from direct assay i "Laminin isoforms in fetal and adult human adrenal cortex.

Proteome Res. DMDM i IIMonroe M. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain.Laminin subunit gamma-1 is a protein that in humans is encoded by the LAMC1 gene.

Lamininsa family of extracellular matrix glycoproteinsare the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma formerly A, B1, and B2, respectively and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains.

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Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described.

Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.

The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes.

Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNAthat multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs 5.

From Wikipedia, the free encyclopedia. Chromosome 1 human [1]. National Center for Biotechnology Information, U.

National Library of Medicine.

lamc1 protein

Cytogenet Cell Genet. DNA Seq. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains".

Laminin gamma 1 Proteins

Matrix Biol. Genome Res. Cell Biol. Cell Sci. Pt 5 : —Consumers are also changing their habits regarding what they do after reading a positive review. The findings are solely concerned with reviews for local business services and not general product reviews.

Based on the views of a representative sample of 1,031 US-based consumers, this survey was conducted in October 2017 with an expert consumer panel. Averages in Q10 and Q12 are based on the midpoints of each banding.

Publishers are welcome to use charts and data crediting BrightLocal and linking to the report. Checking consumer reviews has become a key part of choosing a local business, with more consumers than ever turning to the internet for help with everyday decisions. These incremental increases suggest consumers are seeking out local businesses more than ever. Nearly every consumer now conducts regular local searches, placing expectations on businesses to be visible online.

Some businesses can struggle to differentiate from their competitors, so a positive online reputation is useful to help customers make a choice. Restaurants, hotels and medical providers again lead the pack as the sectors in which most reviews are read. Here we see a clear correlation between regularity of service use and review-reading. How often we need to find a good nearby restaurant, grocery store or bar far outweighs the frequency that we need locksmiths, accountants and chiropractors, for example.

The use of tablets and mobiles to read reviews has increased every year. With Yelp attracting 40. While it leads in monthly traffic, there is still some work to be done to cement it as the trusted source of second opinions. This will likely come as Google puts more emphasis on encouraging business owners to collect reviews and consumers to leave them. Despite getting just 6. After moving away from its consumer platform, Foursquare now focuses more on being a data provider with broader business services.

Consumers have clearly noticed the switch and are placing their trust elsewhere. Could Foursquare reviews be close to the end. Reading a positive or negative review is one thing, but what really matters is what the consumer does next.

Do they take the review on board. Do they ignore it. Do they read more reviews. Do they take immediate action to use the business. This trend corroborates with the findings in Q8, where negativity is becoming less of a driver. The results suggest that, while people are now more likely to take action after reading a positive review, negative reviews are less likely to put them off using a business.

This is good news for businesses who already have a strategy in place for encouraging positive reviews and managing negative ones. If such incremental changes continue, could every consumer soon be reading reviews as part of their decision-making process.

Reviews continue to play a key role in establishing the public reputation of a local business, directly influencing how consumers feel about a business. There also appears to be a growing level of apathy or lack of concern about negative reviews.


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